Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.49 |
| ▸ | CHUK | O15111 | 8/20 | 0.49 |
| ▸ | IKBKG | Q9Y6K9 | 7/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021651 | 0.92 | IKBKB (0.50) | IKBKBCHUKIKBKGCCNKCDK12 | |
| SCHEMBL4074601 | 0.88 | IKBKB (0.50) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL14063844 | 0.86 | PIK3CA (0.54) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL14063766 | 0.85 | IKBKB (0.51) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL8312629 | 0.85 | IKBKB (0.56) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL8308337 | 0.85 | NAMPT (0.51) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL8312581 | 0.85 | CDK1 (0.58) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL13590857 | 0.84 | CDK1 (0.54) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL11924743 | 0.84 | GRM5 (0.60) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL11924740 | 0.84 | MTOR (0.51) | IKBKBCHUKIKBKGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |