Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307263 | 0.85 | PTGS1 (0.39) | ALDH1A1KMT2ARAB9ANPC1MEN1 | |
| SCHEMBL8306762 | 0.81 | MEN1 (0.33) | GFERALDH1A1KMT2ARAB9ANPC1 | |
| SCHEMBL8307945 | 0.80 | MEN1 (0.32) | ALDH1A1KMT2ARAB9ANPC1MEN1 | |
| SCHEMBL8303999 | 0.74 | MEN1 (0.34) | GFERALDH1A1KMT2ARAB9ANPC1 | |
| SCHEMBL8881373 | 0.72 | KMT2A (0.35) | ATMGFERALDH1A1MAPTKMT2A | |
| SCHEMBL8309426 | 0.67 | CYP3A4 (0.42) | GFERALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL8308763 | 0.67 | GSK3B (0.42) | ATMGSK3BPKMMAPTKMT2A | |
| SCHEMBL8306256 | 0.67 | MEN1 (0.33) | GFERALDH1A1KMT2ARAB9ANPC1 | |
| SCHEMBL3289108 | 0.62 | GSK3B (0.61) | ATMGSK3BPKMRAB9ANPC1 | |
| SCHEMBL8881006 | 0.61 | ACHE (0.50) | ALDH1A1KMT2ARAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428053-A | Treats alzheimer's disease and other senile dementias | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | claimed |
| EP-0582182-B1 | 1-Aminoacetamidopyrroles and 1-amino-2-(substituted) pyrroles and their use for the treatment of neurodegenerative dysfunctions | HOECHST MARION ROUSSEL INC (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5605925-A | COGNITION ACTIVATOR; ALZHEIMER'S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-02-25 | — | — | US | disclosed |
| US-5576446-A | GLYCINE PARTIAL AGONIST AND ENHANCEMENT OF LEARNING AND MEMORY, TREATMENT OF ALZHEIMER'S | HOECHST MARION ROUSSEL, INC. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5428053-A | Treats alzheimer's disease and other senile dementias | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0582182-A1 | 1-Aminoacetamidopyrroles and 1-amino-2-(substituted) pyrroles and their use for the treatment of neurodegenerative dysfunctions | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5274116-A | 1-aminoacetamidopyrroles and 1-aminoacetamido-2-(substituted)pyrroles and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-12-28 | — | — | US | disclosed |