Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 20/20 | 0.62 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961317 | 0.97 | HRH1 (0.65) | HRH1TACR1TACR2 | |
| SCHEMBL7954488 | 0.94 | HRH1 (0.64) | HRH1TACR1TACR2 | |
| SCHEMBL7955942 | 0.92 | HRH1 (0.64) | HRH1TACR1 | |
| SCHEMBL7947454 | 0.92 | HRH1 (0.65) | HRH1TACR1TACR2 | |
| SCHEMBL7958392 | 0.91 | HRH1 (0.61) | HRH1TACR1 | |
| SCHEMBL7956630 | 0.90 | HRH1 (0.61) | HRH1TACR1 | |
| SCHEMBL7954754 | 0.89 | HRH1 (0.65) | HRH1 | |
| SCHEMBL7961679 | 0.86 | HRH1 (0.64) | HRH1TACR1TACR2 | |
| SCHEMBL7954689 | 0.86 | HRH1 (0.82) | HRH1TACR1TACR2 | |
| SCHEMBL7002577 | 0.86 | SSTR5 (0.52) | HRH1TACR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |