Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591886 | 0.86 | ESR2 (0.57) | NR1H2ESR2DRD2ESR1 | |
| SCHEMBL7745997 | 0.82 | NR1H2 (0.54) | NR1H2ESR2HSD17B3BRD4ATAD2 | |
| SCHEMBL8311268 | 0.81 | DRD2 (0.52) | NR1H2ESR2DRD2 | |
| SCHEMBL7284689 | 0.81 | ESR2 (0.64) | NR1H2ESR2DRD2ESR1 | |
| SCHEMBL29507781 | 0.79 | NR1H2 (1.00) | NR1H2ESR2NPC1RAB9AESR1 | |
| SCHEMBL308035 | 0.79 | NR1H2 (1.00) | NR1H2ESR2NPC1RAB9AESR1 | |
| SCHEMBL2306894 | 0.76 | NR1H2 (0.85) | NR1H2ESR2NPC1RAB9A | |
| SCHEMBL8311248 | 0.76 | HSD17B3 (0.48) | NR1H2HSD17B3DRD2LIPE | |
| SCHEMBL4928220 | 0.74 | NR1H2 (0.85) | NR1H2ESR2BRD4ATAD2NPC1 | |
| SCHEMBL2307910 | 0.74 | ESR2 (0.56) | NR1H2ESR2DRD2PDK2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937723-A1 | Novel sulfonamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |