Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.43 |
| ▸ | ESR1 | P03372 | 5/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738236 | 0.84 | ESR2 (0.43) | NR1H2ESR2ESR1ABHD6PKM | |
| SCHEMBL7738243 | 0.84 | ABHD6 (0.54) | NR1H2ESR2ESR1ABHD6HSD17B3 | |
| SCHEMBL8308725 | 0.82 | NR1H2 (0.65) | NR1H2ESR2ESR1BRD4ATAD2 | |
| SCHEMBL7738183 | 0.80 | DRD2 (0.45) | ESR2ESR1MAPT | |
| SCHEMBL1641841 | 0.76 | ESR1 (0.72) | NR1H2ESR2ESR1ABHD6PKM | |
| SCHEMBL29754116 | 0.76 | ESR1 (0.72) | NR1H2ESR2ESR1ABHD6PKM | |
| Hydrochloric Acid SCHEMBL1639774 | 0.75 | ESR1 (0.70) | NR1H2ESR2ESR1ABHD6PKM | |
| SCHEMBL8007625 | 0.73 | NR1H2 (0.48) | NR1H2ESR2ESR1ABHD6BRD4 | |
| SCHEMBL373718 | 0.73 | ESR1 (0.58) | NR1H2ESR2ESR1ABHD6BRD4 | |
| SCHEMBL3353692 | 0.71 | ESR1 (0.60) | NR1H2ESR2ESR1ABHD6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |