Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 11/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.66 |
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | CLK1 | P49759 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | KIF5B | P33176 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305714 | 0.89 | EGFR (0.68) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL7455338 | 0.84 | KDR (0.73) | KDREPHA2EPHB4ERBB2EGFR | |
| Hydrochloric Acid SCHEMBL7454698 | 0.83 | KDR (0.71) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL22590721 | 0.83 | EGFR (0.80) | KDREPHB4ERBB2EGFRGAK | |
| SCHEMBL8305182 | 0.81 | EGFR (0.80) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL8933754 | 0.81 | EGFR (0.80) | KDREPHA2EPHB4ERBB2EGFR | |
| Hydrochloric Acid SCHEMBL8810665 | 0.80 | EGFR (0.79) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL8309667 | 0.80 | IGF1R (0.67) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL8614905 | 0.80 | BRD4 (0.44) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL907163 | 0.79 | EPHA2 (1.00) | KDREPHA2EPHB4ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |