Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.68 |
| ▸ | RET | P07949 | 4/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.57 |
| ▸ | KIF5B | P33176 | 2/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.55 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.55 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308738 | 0.89 | KDR (0.66) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL7455338 | 0.89 | KDR (0.73) | EGFRERBB2RETCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL7454698 | 0.88 | KDR (0.71) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL8308795 | 0.82 | KDR (0.74) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL8306859 | 0.81 | EGFR (1.00) | EGFRERBB2RETCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL8309362 | 0.80 | EGFR (0.98) | EGFRERBB2RETCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL8809576 | 0.80 | EGFR (0.76) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL8305107 | 0.79 | EGFR (0.69) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL8307447 | 0.78 | KDR (0.76) | EGFRERBB2RETCLK1ABCG2 | |
| SCHEMBL5565204 | 0.78 | KDR (0.79) | EGFRRETCLK1ABCG2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |