Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618527 | 0.82 | ERBB2 (0.59) | ERBB2STK17BSTK17AIGF1REGFR | |
| SCHEMBL8308738 | 0.80 | KDR (0.66) | EPHB4ERBB2EPHA2KDREGFR | |
| SCHEMBL8618439 | 0.79 | IGF1R (0.62) | ERBB2IGF1REGFRMAP2K1 | |
| Hydrochloric Acid SCHEMBL8620309 | 0.79 | IGF1R (0.61) | ERBB2IGF1REGFRMAP2K1 | |
| SCHEMBL2205050 | 0.78 | KDM4E (0.52) | BRD4EPHB4ERBB2EPHA2KDR | |
| Hydrochloric Acid SCHEMBL8615582 | 0.77 | EGFR (0.45) | EPHB4ERBB2EPHA2KDRSTK17B | |
| SCHEMBL7801861 | 0.73 | KDM4E (0.55) | KDRSTK17AMAPTEGFRMAP2K1 | |
| SCHEMBL8614901 | 0.71 | BCL6 (0.42) | BRD4EPHB4KDRSTK17BSTK17A | |
| SCHEMBL360021 | 0.71 | EGFR (0.53) | KDRMAPTEGFRFLT3RET | |
| SCHEMBL28221880 | 0.70 | PDGFRB (0.64) | ERBB2MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |