Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.74 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.74 |
| ▸ | EGFR | P00533 | 12/20 | 0.73 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.61 |
| ▸ | KIF5B | P33176 | 2/20 | 0.61 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.60 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8809576 | 0.89 | EGFR (0.76) | KDREPHA2ERBB2EGFRCLK1 | |
| SCHEMBL7454466 | 0.88 | KDR (0.78) | KDREPHA2ERBB2EGFRCLK1 | |
| SCHEMBL8307447 | 0.88 | KDR (0.76) | KDREPHA2ERBB2EGFRCLK1 | |
| Hydrochloric Acid SCHEMBL7455631 | 0.87 | KDR (0.77) | KDREPHA2ERBB2EGFRCLK1 | |
| SCHEMBL8309890 | 0.86 | EGFR (0.65) | KDREPHA2ERBB2EGFRCLK1 | |
| SCHEMBL907195 | 0.85 | KDR (1.00) | KDREPHA2ERBB2EGFRFLT1 | |
| SCHEMBL8306859 | 0.84 | EGFR (1.00) | KDRERBB2EGFRCLK1ABCG2 | |
| SCHEMBL8305451 | 0.84 | EGFR (0.63) | KDRERBB2EGFRCLK1ABCG2 | |
| SCHEMBL7460056 | 0.84 | KDR (0.67) | KDREPHA2ERBB2EGFRCLK1 | |
| Hydrochloric Acid SCHEMBL8309362 | 0.83 | EGFR (0.98) | KDRERBB2EGFRCLK1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |