Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635235 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAOBIDO1PARP15PARP14 | |
| SCHEMBL6634917 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAOBIDO1PARP15PARP14 | |
| SCHEMBL4800096 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAOBIDO1PARP15PARP14 | |
| SCHEMBL3822106 | 0.84 | PPARG (0.45) | ALDH1A1MAOBPARP15PARP14PARP10 | |
| SCHEMBL6633456 | 0.81 | MMP1 (0.41) | ALDH1A1KDM4ELMNAPPARGPPARA | |
| SCHEMBL5172388 | 0.81 | MMP1 (0.41) | ALDH1A1KDM4ELMNAPPARGPPARA | |
| SCHEMBL10314840 | 0.78 | IDO1 (0.55) | ALDH1A1MAOBIDO1PARP15PARP14 | |
| SCHEMBL19765221 | 0.77 | ALDH1A1 (0.54) | ALDH1A1MAOBIDO1PARP15PARP14 | |
| SCHEMBL138280 | 0.77 | KMT2A (0.56) | ALDH1A1MAOBLMNAHTTMMP9 | |
| SCHEMBL138281 | 0.77 | KMT2A (0.56) | ALDH1A1MAOBLMNAHTTMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906310-A4 | OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO INC (US) | 1999-09-01 | — | — | EP | disclosed |
| EP-0906310-A1 | OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997046556-A1 | OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO., INC. (US) | 1997-12-11 | — | — | WO | disclosed |