Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.52 |
| ▸ | ATP6V1B1 | P15313 | 3/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308921 | 1.00 | ATP6AP1 (0.52) | ATP6AP1ATP6V1B1TTRDPP4P2RY12 | |
| SCHEMBL2239744 | 0.80 | ATP6V1B1 (0.51) | ATP6V1B1TTRDPP4P2RY12CA12 | |
| SCHEMBL2239741 | 0.80 | ATP6V1B1 (0.51) | ATP6V1B1TTRDPP4P2RY12CA12 | |
| SCHEMBL24601171 | 0.79 | CYP2A6 (0.44) | TTRDPP4P2RY12CA12CA1 | |
| SCHEMBL6295560 | 0.78 | ATP6AP1 (0.53) | ATP6AP1ATP6V1B1CYP3A4KDM4E | |
| SCHEMBL6295563 | 0.78 | ATP6AP1 (0.53) | ATP6AP1ATP6V1B1CYP3A4KDM4E | |
| SCHEMBL22074483 | 0.78 | NPC1 (0.50) | TTRDPP4CA2CYP3A4MAPT | |
| SCHEMBL30684333 | 0.78 | TTR (0.42) | TTRDPP4P2RY12CA12CA1 | |
| SCHEMBL26912859 | 0.78 | TTR (0.42) | TTRDPP4P2RY12CA12CA1 | |
| SCHEMBL1420129 | 0.76 | DNTT (0.42) | TTRDPP4P2RY12CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985905-A | USEFUL FOR THE TREATMENT AND/OR PROPHYLAXIS OF DISEASES ASSOCIATED WITH LOSS OF BONE MASS, SUCH AS OSTEOPOROSIS AND RELATED OSTEOPENIC DISEASES, PAGET'S DISEASE, HYPERPARATHYROIDISM AND RELATED DISEASES, ALSO ANTITUMOR | ENCYSIVE PHARMACEUTICALS, INC. | 1999-11-16 | — | — | US | disclosed |
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0912560-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001445-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |
| EP-0802902-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021644-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |