Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.53 |
| ▸ | ATP6V1B1 | P15313 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295560 | 1.00 | ATP6AP1 (0.53) | ATP6AP1ATP6V1B1KDM4EBLMNPSR1 | |
| SCHEMBL15466242 | 0.81 | ALOX15 (0.50) | — | |
| SCHEMBL17908002 | 0.81 | F7 (0.55) | KDM4ELMNA | |
| SCHEMBL17908005 | 0.81 | F7 (0.55) | KDM4ELMNA | |
| SCHEMBL15466243 | 0.81 | ALOX15 (0.50) | — | |
| SCHEMBL8308919 | 0.78 | ATP6AP1 (0.52) | ATP6AP1ATP6V1B1KDM4ECYP3A4 | |
| SCHEMBL8308921 | 0.78 | ATP6AP1 (0.52) | ATP6AP1ATP6V1B1KDM4ECYP3A4 | |
| SCHEMBL8444640 | 0.76 | ATP6AP1 (0.63) | ATP6AP1ATP6V1B1GRIN2DGRIN3BLMNA | |
| SCHEMBL8444639 | 0.76 | ATP6AP1 (0.63) | ATP6AP1ATP6V1B1GRIN2DGRIN3BLMNA | |
| SCHEMBL6292617 | 0.76 | ATP6AP1 (0.56) | ATP6AP1ATP6V1B1KDM4EBLMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903117-B2 | Indole derivatives for the treatment of osteoporosis | NIKEM RESEARCH S.R.L. (IT) | 2005-06-07 | — | — | US | disclosed |
| EP-0914321-B1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | NIKEM RESEARCH SRL (IT) | 2004-09-22 | — | — | EP | disclosed |
| US-20040010012-A1 | Selective inhibitor of the biological activity of human osteoclast cells | SMITHKLINE BEECHAM SPA | 2004-01-15 | — | — | US | disclosed |
| US-20020173659-A1 | Indole derivatives for the treatment of osteoporosis | SMITH KLINE BEECHAM SPA | 2002-11-21 | — | — | US | disclosed |
| EP-0914321-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1999-05-12 | — | — | EP | disclosed |
| WO-1998001443-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010012-A1 | Selective inhibitor of the biological activity of human osteoclast cells | HRH4, HRH3, CNKSR1 | ATP6AP1 2965/4885ATP6V1B1 2556/4885KDM4E 43/4885 |
| US-20020173659-A1 | Indole derivatives for the treatment of osteoporosis | SOST, GHRHR, EBP | ATP6AP1 4110/4885ATP6V1B1 2108/4885KDM4E 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.