Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414771 | 0.99 | MAPT (0.40) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Iodide SCHEMBL8309296 | 0.78 | PDE3B (0.49) | MAPTOPRK1SMN1; SMN2PDE3APDE3B | |
| SCHEMBL9414700 | 0.76 | PDE3B (0.50) | MAPTOPRK1SMN1; SMN2PDE3APDE3B | |
| SCHEMBL8306755 | 0.76 | MTNR1A (0.37) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL8714462 | 0.72 | HDAC8 (0.47) | MAPTDRD2DRD3 | |
| SCHEMBL11884613 | 0.72 | MAPT (0.64) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL6957730 | 0.70 | MAPT (0.62) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL6957726 | 0.70 | MAPT (0.62) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL9414973 | 0.70 | SMN1; SMN2 (0.36) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL9414692 | 0.70 | SMN1; SMN2 (0.36) | MAPTNFKB1THPOHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |