Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309991 | 0.98 | SCN5A (0.46) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL5911217 | 0.89 | HRH3 (0.62) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL8307331 | 0.87 | CARM1 (0.48) | HRH3CYP1A2KDM1ACARM1PRMT6 | |
| SCHEMBL4381194 | 0.87 | HRH3 (0.59) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL5910693 | 0.87 | HRH3 (0.57) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL8306447 | 0.85 | CARM1 (0.50) | HRH3CYP1A2KDM1ACARM1PRMT6 | |
| SCHEMBL13661585 | 0.85 | HRH3 (0.56) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL17526233 | 0.84 | HRH3 (0.55) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL17526224 | 0.84 | HRH3 (0.55) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL22005759 | 0.83 | HRH3 (0.50) | HRH3SCN5ASMN1; SMN2CYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |