Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309228 | 1.00 | ALOX5 (0.51) | ALOX5NPC1RAB9AEPHX2MAPT | |
| SCHEMBL8610041 | 1.00 | ALOX5 (0.51) | ALOX5NPC1RAB9AEPHX2MAPT | |
| SCHEMBL4729578 | 0.92 | ALOX5 (0.44) | ALOX5NPC1RAB9AEPHX2ALDH1A1 | |
| SCHEMBL5086216 | 0.92 | ALOX5 (0.44) | ALOX5NPC1RAB9AEPHX2ALDH1A1 | |
| SCHEMBL4729170 | 0.88 | NPC1 (0.45) | ALOX5NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4729172 | 0.88 | NPC1 (0.45) | ALOX5NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8609409 | 0.88 | NPC1 (0.45) | ALOX5NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8613457 | 0.86 | NPC1 (0.44) | ALOX5NPC1RAB9AEPHX2MAPT | |
| SCHEMBL8609455 | 0.85 | NPC1 (0.43) | ALOX5NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8659861 | 0.85 | MAPT (0.51) | ALOX5NPC1RAB9AEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |