Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 13/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729170 | 0.90 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4729172 | 0.90 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8609409 | 0.90 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8613457 | 0.89 | NPC1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8309230 | 0.85 | ALOX5 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8309228 | 0.85 | ALOX5 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8610041 | 0.85 | ALOX5 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4729578 | 0.78 | ALOX5 (0.44) | NPC1RAB9AALDH1A1ALOX5MEN1 | |
| SCHEMBL5086216 | 0.78 | ALOX5 (0.44) | NPC1RAB9AALDH1A1ALOX5MEN1 | |
| SCHEMBL8609779 | 0.76 | ALOX5 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |