Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 6/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24133460 | 0.80 | RIPK2 (0.39) | ADORA1ADORA2AMAPK8MAPK9FLT4 | |
| SCHEMBL8357891 | 0.80 | HPGD (0.51) | ADORA1ADORA2ASMN1; SMN2HPGDRIPK2 | |
| SCHEMBL8308145 | 0.79 | HPGD (0.49) | ADORA1ADORA2AMAPK9FLT4AURKB | |
| SCHEMBL15613500 | 0.78 | ADORA1 (0.47) | ADORA1ADORA2AMAPK8MAPK9FLT4 | |
| SCHEMBL3691443 | 0.78 | KDM4E (0.50) | ADORA1ADORA2ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL8308115 | 0.76 | ADORA2A (0.48) | ADORA1ADORA2AMAPK8MAPK9MAPK10 | |
| SCHEMBL8310247 | 0.76 | KIF11 (0.41) | ADORA1MAPK9FLT4AURKBPRKD2 | |
| SCHEMBL8308524 | 0.75 | RIPK2 (0.60) | RETRIPK2 | |
| SCHEMBL8310316 | 0.74 | ADORA2A (0.51) | ADORA1ADORA2APIK3CDPIK3CGHPGD | |
| SCHEMBL8310297 | 0.74 | SRC (0.61) | ADORA1ADORA2AMAPK8DYRK1AAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |