Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 11/20 | 0.60 |
| ▸ | SRC | P12931 | 5/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261283 | 0.81 | RIPK2 (0.70) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8308306 | 0.81 | RIPK2 (0.74) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8357880 | 0.80 | RIPK2 (0.72) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL5618684 | 0.80 | RIPK2 (0.68) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL6646290 | 0.78 | RIPK2 (0.67) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8356091 | 0.78 | RIPK2 (0.74) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8362338 | 0.76 | RIPK2 (0.64) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8359666 | 0.76 | RIPK2 (0.60) | RIPK2SRCLCKKDRTGFBR1 | |
| SCHEMBL8309258 | 0.75 | ADORA1 (0.48) | RIPK2RET | |
| SCHEMBL24410875 | 0.74 | RIPK2 (0.61) | RIPK2SRCLCKKDRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |