Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8309441 | 0.96 | EGFR (0.59) | EGFRMAPK14AURKBIRAK4FGFR1 | |
| SCHEMBL8309364 | 0.93 | EGFR (0.70) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8307571 | 0.92 | EGFR (0.69) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8307965 | 0.89 | EGFR (0.65) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8304875 | 0.87 | AURKB (0.69) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8813291 | 0.85 | KDR (0.67) | EGFRMAPK14AURKBFLT1AURKA | |
| SCHEMBL8306628 | 0.84 | EGFR (0.66) | EGFRAURKBAURKAHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL8310307 | 0.82 | KDR (0.80) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8310283 | 0.80 | KDR (0.63) | EGFRMAPK14AURKBFLT1AURKA | |
| SCHEMBL18158156 | 0.80 | AURKB (0.80) | EGFRMAPK14AURKBIRAK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |