Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 11/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | FLT4 | P35916 | 1/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.62 |
| ▸ | TEK | Q02763 | 1/20 | 0.62 |
| ▸ | KIF5B | P33176 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8307571 | 0.99 | EGFR (0.69) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8307965 | 0.95 | EGFR (0.65) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8304875 | 0.93 | AURKB (0.69) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8309261 | 0.93 | EGFR (0.64) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8813291 | 0.91 | KDR (0.67) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL8306628 | 0.90 | EGFR (0.66) | EGFRAURKBAURKAKDRRET | |
| Hydrochloric Acid SCHEMBL8309441 | 0.89 | EGFR (0.59) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8310283 | 0.87 | KDR (0.63) | EGFRMAPK14AURKBAURKAKDR | |
| Hydrochloric Acid SCHEMBL8310307 | 0.86 | KDR (0.80) | EGFRMAPK14AURKBAURKAKDR | |
| SCHEMBL18158156 | 0.86 | AURKB (0.80) | EGFRMAPK14AURKBAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | claimed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |