Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194869 | 0.81 | KDM4E (0.65) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL1421461 | 0.80 | ABCG2 (0.87) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL4167435 | 0.76 | ABCG2 (0.70) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL16160553 | 0.75 | MAPT (0.63) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL4285872 | 0.74 | KDM4E (1.00) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL30139617 | 0.74 | KDM4E (1.00) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL15676607 | 0.74 | KDM4E (1.00) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL16150328 | 0.74 | TP53 (0.58) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL31031141 | 0.73 | ABCG2 (0.60) | ABCG2KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL15690698 | 0.72 | ACE2 (0.64) | ABCG2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |