Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL8309485

NNCCCO.O=C(O)C(F)(F)F

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.43
ALDH1A1 P00352 2/20 0.37
POLB P06746 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
FUCA1 P04066 1/20 0.34
CA3 P07451 2/20 0.32
CA5A P35218 2/20 0.32
CA5B Q9Y2D0 2/20 0.32
CA12 O43570 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
CAMK2A Q9UQM7 1/20 0.32
PTGS1 P23219 1/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL31384187 0.78 GPR84 (0.46) ALDH1A1POLBSMN1; SMN2MEN1KMT2A
SCHEMBL3273840 0.78
Trifluoroacetic Acid SCHEMBL31376907 0.78 HDAC6 (0.43) ALOX15ALDH1A1POLBSMN1; SMN2MEN1
Trifluoroacetic Acid SCHEMBL28782661 0.78 ALOX15 (0.59) ALOX15MEN1KMT2AS1PR1S1PR3
Trifluoroacetic Acid SCHEMBL5548189 0.76 HDAC6 (0.54) ALOX15SMN1; SMN2MEN1KMT2ACA3
Trifluoroacetic Acid SCHEMBL31384178 0.76 GPR84 (0.50) ALDH1A1SMN1; SMN2MEN1KMT2ACAMK2A
Trifluoroacetic Acid SCHEMBL31384180 0.76 GPR84 (0.50) ALDH1A1SMN1; SMN2MEN1KMT2ACAMK2A
Trifluoroacetic Acid SCHEMBL7455642 0.76 ALOX15 (0.50) ALOX15MEN1KMT2AFUCA1S1PR1
Trifluoroacetic Acid SCHEMBL27997235 0.76 ALOX15 (0.50) ALOX15MEN1KMT2AFUCA1S1PR1
Hydrochloric Acid SCHEMBL21598364 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922741-A 5-aminopyrazoles useful as tyrosine kinase inhibitors CELLTECH THERAPEUTICS LTD. (GB) 1999-07-13 US disclosed
EP-0906286-A1 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK CELLTECH THERAPEUTICS LIMITED (GB) 1999-04-07 EP disclosed
WO-1997040019-A1 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK CELLTECH THERAPEUTICS LIMITED (GB) 1997-10-30 WO disclosed