Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24651034 | 0.91 | GRIN2B (0.50) | GRIN2BSIGMAR1MAPTPRMT5MTNR1A | |
| SCHEMBL24651033 | 0.87 | NAMPT (0.52) | GRIN2BSIGMAR1MAPTMTNR1AMTNR1B | |
| SCHEMBL24651032 | 0.83 | GRIN2B (0.61) | GRIN2BSIGMAR1MAPTMTNR1AMTNR1B | |
| SCHEMBL8303981 | 0.82 | MCHR1 (0.40) | GRIN2BSIGMAR1MAPTPRMT5ALDH1A1 | |
| SCHEMBL7432153 | 0.81 | PRMT5 (0.50) | GRIN2BSIGMAR1MAPTPRMT5MTNR1A | |
| SCHEMBL9725938 | 0.78 | NAMPT (0.48) | GRIN2BSIGMAR1MAPTMTNR1AMTNR1B | |
| SCHEMBL21851142 | 0.77 | EPHX2 (0.54) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL21376662 | 0.77 | EPHX2 (0.58) | MAPTMTNR1AMTNR1BLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL9725932 | 0.77 | NAMPT (0.47) | GRIN2BSIGMAR1MAPTMTNR1AMTNR1B | |
| SCHEMBL20689713 | 0.76 | GRIN2B (0.73) | GRIN2BSIGMAR1MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022238507-A1 | THERAPEUTIC AMINOINDANE COMPOUNDS AND COMPOSITIONS | AWAKN LS EUROPE HOLDINGS LIMITED (IE) | 2022-11-17 | — | — | WO | disclosed |
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |