Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308769 | 0.91 | TBXAS1 (1.00) | TBXAS1ALDH1A1MAPT | |
| SCHEMBL8309573 | 0.90 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8308551 | 0.87 | TBXAS1 (0.64) | TBXAS1ALDH1A1 | |
| SCHEMBL8304690 | 0.79 | TBXAS1 (0.78) | TBXAS1ALDH1A1 | |
| SCHEMBL8538416 | 0.79 | TBXAS1 (0.88) | TBXAS1 | |
| SCHEMBL8308709 | 0.78 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8310212 | 0.77 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8308771 | 0.75 | TBXAS1 (0.71) | TBXAS1 | |
| SCHEMBL8309517 | 0.74 | TBXAS1 (0.66) | TBXAS1ALDH1A1MAPT | |
| SCHEMBL8595578 | 0.74 | TBXAS1 (0.77) | TBXAS1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |