Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309511 | 0.91 | TBXAS1 (0.83) | TBXAS1ALDH1A1MAPT | |
| SCHEMBL8309573 | 0.91 | TBXAS1 (1.00) | TBXAS1TBXA2R | |
| SCHEMBL8304690 | 0.88 | TBXAS1 (0.78) | TBXAS1ALDH1A1TDP1 | |
| SCHEMBL8308771 | 0.83 | TBXAS1 (0.71) | TBXAS1 | |
| SCHEMBL8308551 | 0.78 | TBXAS1 (0.64) | TBXAS1ALDH1A1TDP1 | |
| SCHEMBL8308709 | 0.78 | TBXAS1 (0.77) | TBXAS1TBXA2R | |
| SCHEMBL8309213 | 0.77 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL11109404 | 0.77 | ALDH1A1 (0.91) | TBXAS1ALDH1A1MAPTTBXA2RTDP1 | |
| SCHEMBL8309534 | 0.74 | TBXAS1 (1.00) | TBXAS1ALDH1A1MAPTTBXA2R | |
| SCHEMBL11477599 | 0.74 | TBXAS1 (1.00) | TBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |