Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310078 | 0.96 | LSS (0.83) | LSSALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL6182258 | 0.94 | LSS (1.00) | LSSALDH1A1NPC1RAB9APKM | |
| SCHEMBL6977994 | 0.91 | LSS (0.93) | LSSALDH1A1NPC1RAB9APKM | |
| SCHEMBL6977537 | 0.90 | LSS (0.93) | LSSALDH1A1NPC1RAB9AUSP2 | |
| SCHEMBL6977387 | 0.83 | LSS (0.76) | LSSALDH1A1LMNAHSD17B10POLB | |
| SCHEMBL6980932 | 0.81 | LSS (0.77) | LSSALDH1A1NPC1RAB9ACNR1 | |
| SCHEMBL6974183 | 0.81 | LSS (0.76) | LSSNPC1RAB9ACNR1F10 | |
| SCHEMBL6978604 | 0.80 | LSS (0.71) | LSSALDH1A1LMNAHSD17B10POLB | |
| SCHEMBL7336119 | 0.79 | LSS (1.00) | LSSALDH1A1PKMCNR1F10 | |
| SCHEMBL6981493 | 0.78 | LSS (0.69) | LSSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |