Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.83 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309729 | 0.96 | LSS (0.89) | LSSNPC1RAB9AALDH1A1POLB | |
| SCHEMBL6977994 | 0.95 | LSS (0.93) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6182258 | 0.91 | LSS (1.00) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6977537 | 0.87 | LSS (0.93) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6980932 | 0.86 | LSS (0.77) | LSSNPC1RAB9AALDH1A1 | |
| SCHEMBL6978604 | 0.84 | LSS (0.71) | LSSALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL6975859 | 0.82 | LSS (0.71) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6977387 | 0.80 | LSS (0.76) | LSSALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL6977459 | 0.80 | LSS (0.93) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6980904 | 0.79 | LSS (0.68) | LSSNPC1RAB9AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |