Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11863909 | 0.89 | KIF11 (0.39) | CYP19A1MAOBMEN1KIF11CYP11B1 | |
| SCHEMBL8306983 | 0.85 | TAAR1 (0.40) | CYP19A1MAOBGRIN1GRIN2BMEN1 | |
| SCHEMBL8099648 | 0.83 | CYP19A1 (0.36) | CYP19A1TTBK1TTBK2LMNASMN1; SMN2 | |
| Trityl Imidazole SCHEMBL1572623 | 0.78 | MTOR (0.45) | CYP19A1LMNASMN1; SMN2MEN1CYP11B1 | |
| SCHEMBL8309765 | 0.75 | LMNA (0.40) | CYP19A1CHEK2MAOBCSNK1A1CSNK1D | |
| SCHEMBL11089506 | 0.75 | MTOR (0.45) | CYP19A1LMNASMN1; SMN2MEN1CYP11B1 | |
| SCHEMBL9669719 | 0.75 | TAAR1 (0.36) | CYP19A1LMNASMN1; SMN2 | |
| SCHEMBL1484199 | 0.73 | CYP19A1 (0.41) | CYP19A1KIF11 | |
| SCHEMBL5738213 | 0.73 | NISCH (0.43) | CYP19A1LMNASMN1; SMN2MEN1KIF11 | |
| SCHEMBL3827055 | 0.73 | CYP19A1 (0.41) | CYP19A1CSNK1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |