Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445339 | 0.79 | BACE1 (0.40) | MEN1KMT2AHTTALDH1A1TSHR | |
| SCHEMBL7553115 | 0.73 | PDE4D (0.39) | MEN1KMT2ANPSR1HTTALDH1A1 | |
| SCHEMBL7120307 | 0.72 | HIF1A (0.36) | MEN1KMT2AHTTALDH1A1L3MBTL1 | |
| SCHEMBL13219265 | 0.72 | CNR1 (0.32) | — | |
| SCHEMBL7128812 | 0.71 | MAPT (0.40) | ELANEMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL5181404 | 0.70 | KLKB1 (0.40) | ELANEMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL30003172 | 0.69 | ALOX15 (0.50) | ELANEMEN1KMT2AALOX15NPSR1 | |
| SCHEMBL13219268 | 0.68 | GPR84 (0.37) | MEN1KMT2AALDH1A1PTPN1 | |
| SCHEMBL7888138 | 0.67 | HTT (0.36) | MEN1KMT2ANPSR1HTTALDH1A1 | |
| SCHEMBL10102247 | 0.67 | KLKB1 (0.37) | MEN1KMT2AALDH1A1L3MBTL1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954761-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG Industries Ohio, Inc. (US) | 1999-11-10 | — | — | EP | claimed |
| EP-0954761-A4 | — | — | 1999-11-10 | — | — | EP | claimed |
| US-5744070-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1998-04-28 | — | — | US | claimed |
| WO-1997022895-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1997-06-26 | — | — | WO | claimed |
| EP-0954761-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG Industries Ohio, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| EP-0954761-A4 | — | — | 1999-11-10 | — | — | EP | disclosed |
| US-5744070-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1997022895-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1997-06-26 | — | — | WO | disclosed |