Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6115316 | 0.82 | TRIM24 (0.39) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL2085063 | 0.81 | GABRA1 (0.42) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL3823757 | 0.80 | TRIM24 (0.38) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL18250821 | 0.80 | TRIM24 (0.38) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4005646 | 0.80 | DPP4 (0.42) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL3296819 | 0.80 | KDM4E (0.42) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| Benzene SCHEMBL11824212 | 0.78 | TRIM24 (0.37) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4229224 | 0.77 | HTT (0.45) | TRIM24TRIM33ALDH1A1KDM4EMAPT | |
| SCHEMBL18995128 | 0.77 | TKT (0.37) | TRIM24TRIM33ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL11552786 | 0.77 | MET (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948257-A4 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 1999-12-29 | — | — | EP | disclosed |
| EP-0948257-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5955480-A | GLUCAGON RECEPTOR ANTAGONISTS, CYTOKINE INHIBITORS | MERCK & CO., INC. (US) | 1999-09-21 | — | — | US | disclosed |
| WO-1998021957-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |