Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721355 | 0.90 | PAOX (0.64) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL8309738 | 0.88 | KDM1A (0.46) | PAOXHPGDDUSP3CYP2D6KDM1A | |
| Hydrochloric Acid SCHEMBL2488967 | 0.88 | PAOX (0.62) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL8310934 | 0.85 | KDM1A (0.48) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL4398803 | 0.84 | PAOX (0.62) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL8310330 | 0.82 | KEAP1 (0.67) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL8310657 | 0.82 | SCN5A (0.46) | PAOXKDM1ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL10151331 | 0.81 | KEAP1 (0.70) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL3200520 | 0.81 | PAOX (0.59) | PAOXHPGDDUSP3CYP2C19CYP3A4 | |
| SCHEMBL13376034 | 0.81 | PAOX (0.55) | PAOXHPGDDUSP3CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |