Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310405 | 1.00 | PPARG (0.44) | PPARGALOX5RAB9AFFAR1PPARA | |
| SCHEMBL8306302 | 0.86 | PPARG (0.49) | PPARGFFAR1PPARA | |
| SCHEMBL8306303 | 0.86 | PPARG (0.49) | PPARGFFAR1PPARA | |
| SCHEMBL8306453 | 0.86 | PPARG (0.49) | PPARGFFAR1RARGRXRA | |
| SCHEMBL8306456 | 0.86 | PPARG (0.49) | PPARGFFAR1RARGRXRA | |
| SCHEMBL8305220 | 0.85 | PPARG (0.46) | PPARGFFAR1PPARARARGRXRA | |
| SCHEMBL8305218 | 0.85 | PPARG (0.46) | PPARGFFAR1PPARARARGRXRA | |
| SCHEMBL8307060 | 0.83 | PPARG (0.55) | PPARGFFAR1 | |
| SCHEMBL8307062 | 0.83 | PPARG (0.55) | PPARGFFAR1 | |
| SCHEMBL8305087 | 0.83 | PPARG (0.51) | PPARGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972959-A | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0708098-B1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1999-03-03 | — | — | EP | disclosed |
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0708098-A1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |