Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.56 |
| ▸ | CHUK | O15111 | 4/20 | 0.56 |
| ▸ | IKBKG | Q9Y6K9 | 3/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | DKK1 | O94907 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063828 | 0.91 | CAMK2D (0.61) | IKBKBCHUKIKBKGCAMK2DMTOR | |
| SCHEMBL14021219 | 0.87 | PIK3CA (0.58) | IKBKBCHUKIKBKGCAMK2DMTOR | |
| SCHEMBL14021251 | 0.86 | JAK2 (0.57) | IKBKBCHUKIKBKGCAMK2DPIK3CG | |
| SCHEMBL14021222 | 0.86 | PIK3CA (0.53) | IKBKBCHUKIKBKGCAMK2DMTOR | |
| SCHEMBL1512786 | 0.86 | PIK3CA (0.55) | IKBKBCHUKIKBKGCAMK2DPIK3CG | |
| SCHEMBL8312148 | 0.86 | CDK1 (0.62) | IKBKBCHUKCAMK2DPIK3CGPIK3CA | |
| SCHEMBL14021190 | 0.86 | MTOR (0.60) | IKBKBCHUKIKBKGCAMK2DMTOR | |
| SCHEMBL11924733 | 0.86 | MTOR (0.60) | IKBKBCHUKIKBKGCAMK2DMTOR | |
| SCHEMBL8311767 | 0.86 | SYK (0.56) | — | |
| SCHEMBL28954223 | 0.85 | PIK3CA (0.52) | IKBKBCHUKIKBKGCAMK2DMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |