Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307483 | 0.83 | ALDH1A1 (0.66) | ALDH1A1NPSR1HPGDHCAR1CRHR1 | |
| SCHEMBL8536677 | 0.83 | L3MBTL1 (0.37) | L3MBTL1DAO | |
| SCHEMBL27469414 | 0.81 | ALDH1A1 (0.46) | ALDH1A1NPSR1HPGDL3MBTL1CRHR1 | |
| SCHEMBL8306574 | 0.81 | ALDH1A1 (0.46) | ALDH1A1NPSR1HPGDL3MBTL1CRHR1 | |
| SCHEMBL27471787 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDL3MBTL1HCAR1CRHR1 | |
| SCHEMBL12900953 | 0.77 | ALDH1A1 (0.46) | ALDH1A1NPSR1HPGDFFAR4L3MBTL1 | |
| SCHEMBL14502271 | 0.77 | ALDH1A1 (0.43) | ALDH1A1NPSR1HPGDL3MBTL1HCAR1 | |
| SCHEMBL22601569 | 0.72 | MAP3K5 (0.45) | MAP3K5NPSR1CCR1CCR2FFAR4 | |
| SCHEMBL8306550 | 0.72 | MAP3K5 (0.40) | ALDH1A1MAP3K5NPSR1HPGDCCR1 | |
| SCHEMBL3858469 | 0.72 | CMA1 (0.43) | ALDH1A1HPGDL3MBTL1HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427556-B2 | Urea derivatives as inhibitors of ASK1 | Hepagene Therapeutics (HK) Limited (HK) | 2022-08-30 | — | — | US | disclosed |
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | HEPAGENE THERAPEUTICS, INC. (VG) | 2020-10-29 | — | — | US | disclosed |
| CN-111433198-A | Urea derivatives as inhibitors of ASK1 | 合帕吉恩治疗公司 | 2020-07-17 | — | — | CN | disclosed |
| US-20070135428-A1 | LACTAM CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | QIAO JENNIFER X | 2007-06-14 | — | — | US | disclosed |
| US-20070135428-A1 | LACTAM CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | QIAO JENNIFER X | 2007-06-14 | — | — | US | disclosed |
| US-7205318-B2 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205318-B2 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2004082687-A1 | LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11427556-B2 | Urea derivatives as inhibitors of ASK1 | ATF1, ERN1, MAP3K1 | ALDH1A1 1908/4885MAP3K5 18/4885NPSR1 4687/4885 |
| US-20070135428-A1 | LACTAM CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | F12, F2, PEPD | ALDH1A1 3204/4885MAP3K5 3042/4885NPSR1 2220/4885 |
| US-20200339530-A1 | UREA DERIVATIVES AS INHIBITORS OF ASK1 | ATF1, ERN1, MAP3K1 | ALDH1A1 1908/4885MAP3K5 18/4885NPSR1 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.