Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310543 | 0.80 | CYP1A2 (0.56) | KMT2AKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL8315301 | 0.80 | KMT2A (1.00) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL196599 | 0.80 | KMT2A (1.00) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL954146 | 0.77 | KMT2A (0.76) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL954228 | 0.75 | KMT2A (0.64) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL15747676 | 0.75 | KMT2A (0.64) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL2937795 | 0.75 | KMT2A (0.73) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL954303 | 0.75 | KMT2A (0.73) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL8317131 | 0.75 | ALDH1A1 (0.46) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL8312175 | 0.75 | EPHB3 (0.49) | KMT2AKDM4EALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |