Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312406 | 0.79 | CYP1A2 (0.46) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL8311161 | 0.79 | CYP1A2 (0.46) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL9286867 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL8311289 | 0.77 | SMN1; SMN2 (0.59) | ALDH1A1KDM4ESMN1; SMN2KMT2ARAB9A | |
| SCHEMBL4063787 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL8312072 | 0.75 | KMT2A (0.67) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL9098286 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL8816352 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL7502575 | 0.72 | SMN1; SMN2 (0.78) | ALDH1A1KDM4EGAALMNAGLA | |
| SCHEMBL7013857 | 0.72 | KDM4E (0.51) | ALDH1A1KDM4EGAALMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |