Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841665 | 1.00 | PDE6D (0.37) | PDE6DKMT2ATSHRHTR1AHTR2A | |
| SCHEMBL8313412 | 0.91 | ALDH1A1 (0.36) | PDE6DKMT2ATSHRMEN1DDB1 | |
| SCHEMBL4845001 | 0.91 | ALDH1A1 (0.36) | PDE6DKMT2ATSHRMEN1DDB1 | |
| SCHEMBL4841426 | 0.86 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL8319687 | 0.86 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL5791548 | 0.78 | MEN1 (0.36) | KMT2AMEN1TDP1MAPTNPSR1 | |
| SCHEMBL4833492 | 0.78 | MEN1 (0.36) | KMT2AMEN1TDP1MAPTNPSR1 | |
| SCHEMBL4841479 | 0.78 | MEN1 (0.36) | KMT2AMEN1TDP1MAPTNPSR1 | |
| SCHEMBL8313398 | 0.76 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL4838497 | 0.76 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |