Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838497 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTNPSR1HTTTDP1 | |
| SCHEMBL4833337 | 0.84 | NPSR1 (0.34) | ALDH1A1MAPTNPSR1TDP1KMT2A | |
| SCHEMBL8313412 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAPTNPSR1HTTTDP1 | |
| SCHEMBL8314206 | 0.84 | NPSR1 (0.34) | ALDH1A1MAPTNPSR1TDP1KMT2A | |
| SCHEMBL4845001 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAPTNPSR1HTTTDP1 | |
| SCHEMBL14254617 | 0.81 | ALDH1A1 (0.37) | ALDH1A1MAPTHTTKMT2ACTDSP1 | |
| SCHEMBL4843406 | 0.81 | ALDH1A1 (0.37) | ALDH1A1MAPTHTTKMT2ACTDSP1 | |
| SCHEMBL5791105 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1HTTTDP1 | |
| SCHEMBL4839870 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1HTTTDP1 | |
| SCHEMBL4843507 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |