Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635608 | 0.75 | GSK3B (0.43) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL29445518 | 0.73 | POLB (0.58) | METAP2PDPK1AURKAMAPTMEN1 | |
| SCHEMBL7885794 | 0.73 | POLB (0.58) | METAP2PDPK1AURKAMAPTMEN1 | |
| SCHEMBL3344891 | 0.71 | METAP2 (0.49) | METAP2TSHRRECQLPDPK1AURKA | |
| SCHEMBL1528759 | 0.70 | HSD17B10 (0.62) | TSHRRECQLMAPTMEN1HPGD | |
| SCHEMBL16861335 | 0.69 | METAP2 (0.49) | METAP2TSHRMAPTMEN1HPGD | |
| SCHEMBL654803 | 0.67 | METAP2 (0.56) | METAP2TSHRRECQLPDPK1AURKA | |
| SCHEMBL457676 | 0.67 | POLB (0.55) | MAPTMEN1HPGDKMT2ALMNA | |
| SCHEMBL10066830 | 0.67 | CYP1A2 (0.62) | METAP2TSHRRECQLPDPK1AURKA | |
| SCHEMBL27421814 | 0.67 | MEN1 (0.54) | METAP2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089911-A1 | PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |