Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.78 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.66 |
| ▸ | GSK3B | P49841 | 3/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | IKBKB | O14920 | 8/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | DKK1 | O94907 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073695 | 0.92 | MAPK8 (0.65) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL4073555 | 0.91 | MAPK8 (0.67) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL4064743 | 0.90 | IKBKB (0.70) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL4834740 | 0.89 | MAPK8 (0.69) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL13911505 | 0.89 | IKBKB (0.64) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL8246523 | 0.88 | MAPK8 (1.00) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL14021411 | 0.86 | CAMK2D (0.60) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL4800404 | 0.85 | MAPK8 (0.83) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL14020959 | 0.83 | MAPK8 (0.80) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL8312461 | 0.81 | MAPK8 (0.77) | MAPK8MAPK10CAMKK2GSK3BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349841-B1 | ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-12-02 | — | — | EP | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |