Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324789 | 1.00 | CHRM1 (0.45) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL18347995 | 0.91 | CHRM2 (0.52) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL12920577 | 0.91 | CHRM2 (0.52) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL18347958 | 0.91 | CHRM2 (0.52) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL14577530 | 0.76 | CHRM3 (0.48) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL14611981 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL14611982 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL10280321 | 0.76 | CHRM3 (0.48) | CHRM1CHRM2CHRM3CA12CA1 | |
| SCHEMBL14611984 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL14577614 | 0.76 | CHRM3 (0.48) | CHRM1CHRM2CHRM3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052348-A2 | TREATMENT OF DISEASES WITH COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS AND OTHER COMPOUNDS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004039366-A1 | NICOTINIC ACETYLCHOLINE AGONISTS IN THE TREATMENT OF GLAUCOMA AND RETINAL NEUROPATHY | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-05-13 | — | — | WO | disclosed |