Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325137 | 1.00 | CHRM3 (0.48) | CHRM3CHRM1CHRM2CA12CA1 | |
| SCHEMBL14577530 | 1.00 | CHRM3 (0.48) | CHRM3CHRM1CHRM2CA12CA1 | |
| SCHEMBL14577614 | 1.00 | CHRM3 (0.48) | CHRM3CHRM1CHRM2CA12CA1 | |
| SCHEMBL843533 | 0.79 | CTSK (0.47) | CHRM3CHRM1CHRM2CA1CA2 | |
| SCHEMBL8324789 | 0.76 | CHRM1 (0.45) | CHRM3CHRM1CHRM2CA12CA1 | |
| SCHEMBL14611981 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL14611983 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL14611982 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL14611984 | 0.76 | CHRM1 (0.45) | CHRM1CA12CA1CA2CA9 | |
| SCHEMBL8312751 | 0.76 | CHRM1 (0.45) | CHRM3CHRM1CHRM2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | disclosed |
| US-7176198-B2 | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease | PFIZER INC. (US) | 2007-02-13 | — | — | US | disclosed |