Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | CARS1 | P49589 | 1/20 | 0.46 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.46 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 7/20 | 0.45 |
| ▸ | FBP1 | P09467 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314998 | 0.90 | BRAF (0.51) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL8318130 | 0.87 | EGFR (0.54) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL8314587 | 0.85 | EGFR (0.60) | EGFRBRAF | |
| SCHEMBL8315732 | 0.85 | EGFR (0.60) | EGFR | |
| SCHEMBL8319394 | 0.85 | EGFR (0.50) | EGFRERBB2BRAFMAPT | |
| SCHEMBL8318621 | 0.82 | ABCG2 (0.52) | EGFRBRAF | |
| SCHEMBL7574919 | 0.81 | BRAF (0.45) | EGFRGAKERBB2ERBB4BRAF | |
| SCHEMBL8318461 | 0.80 | EGFR (0.55) | EGFRERBB2BRAFMAPT | |
| SCHEMBL8314683 | 0.79 | CSNK2A1 (0.55) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL8320166 | 0.78 | EGFR (0.67) | EGFRERBB2ERBB4BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |