Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569353 | 0.80 | HRH3 (0.69) | HRH3 | |
| SCHEMBL16843151 | 0.79 | CYP2D6 (0.69) | CYP2D6HRH3 | |
| SCHEMBL17285888 | 0.76 | HTR2A (0.60) | CYP2D6HRH3 | |
| SCHEMBL8320205 | 0.74 | HTR2A (0.54) | HRH3 | |
| Methimepip SCHEMBL8320104 | 0.73 | HRH3 (0.51) | HRH3 | |
| SCHEMBL3577327 | 0.71 | HRH3 (0.69) | HRH3 | |
| SCHEMBL22878461 | 0.67 | HTR2A (0.48) | CYP2D6HRH3 | |
| SCHEMBL17284448 | 0.66 | HTR2A (0.47) | CYP2D6HRH3 | |
| SCHEMBL17286035 | 0.66 | HTR2A (0.56) | — | |
| SCHEMBL17285945 | 0.66 | LTA4H (0.56) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| WO-2004066960-A2 | COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS | SCHERING CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |