Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | PRKCB | P05771 | 2/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | PRKACG | P22612 | 3/20 | 0.48 |
| ▸ | PRKACB | P22694 | 3/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376063 | 0.79 | PRKACA (0.68) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL14560481 | 0.76 | SIRT2 (0.69) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL28006399 | 0.75 | SIRT2 (0.52) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL7193605 | 0.74 | SIRT2 (1.00) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL30657539 | 0.74 | CYP1B1 (0.62) | CYP1B1 | |
| SCHEMBL8247166 | 0.74 | CYP1B1 (0.62) | CYP1B1 | |
| SCHEMBL8478365 | 0.72 | SIRT2 (0.63) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL14560480 | 0.72 | SIRT2 (0.67) | SIRT2SIRT1PRKCBPRKACAPRKACG | |
| SCHEMBL8318323 | 0.72 | NQO1 (0.59) | PRKCBCYP1B1PRKACAPRKACGPRKACB | |
| SCHEMBL30958473 | 0.71 | SIRT2 (1.00) | SIRT2SIRT1PRKCBPRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630242-B1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | WELLCOME FOUND (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5547976-A | VIRICIDES, HERPES VIRUS, CYTOMEGALOVIRUS; CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| EP-0630241-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018765-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |