Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 11/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268707 | 0.88 | PDE4A (0.53) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8319979 | 0.82 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8270483 | 0.82 | PDE4A (0.66) | ALDH1A1HPGDRAD52NPC1PDE4A | |
| SCHEMBL8321025 | 0.79 | PDE4A (0.50) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8271316 | 0.78 | PDE4A (0.65) | ALDH1A1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL8319800 | 0.76 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986032 | 0.76 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL8269334 | 0.76 | PDE4A (0.67) | NPC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8270548 | 0.74 | PDE4A (0.64) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8268706 | 0.74 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |