Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313341 | 0.88 | ALDH1A1 (0.53) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8270548 | 0.87 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8268708 | 0.82 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8319979 | 0.82 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4818511 | 0.82 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4818514 | 0.82 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8319800 | 0.79 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8321025 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8271316 | 0.78 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8315838 | 0.77 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |