Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.57 |
| ▸ | EED | O75530 | 1/20 | 0.48 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.48 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526289 | 0.85 | GRM5 (0.55) | GRM5EEDRBBP4SUZ12EZH2 | |
| SCHEMBL4010552 | 0.82 | GRM5 (0.64) | GRM5LNPEPPRMT1GRIN2BGRM1 | |
| SCHEMBL2640481 | 0.81 | ALDH1A1 (0.49) | GRM5GRM1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1850198 | 0.81 | CHEK1 (0.62) | GRM5LNPEPBTK | |
| SCHEMBL31198721 | 0.81 | GRM5 (0.53) | GRM5EEDRBBP4SUZ12EZH2 | |
| SCHEMBL8315932 | 0.80 | MEN1 (0.57) | GRM5LNPEPPRMT1MEN1KMT2A | |
| SCHEMBL1577497 | 0.80 | GRM5 (0.56) | GRM5EEDRBBP4SUZ12EZH2 | |
| SCHEMBL26112816 | 0.80 | GRM5 (0.48) | GRM5EEDRBBP4SUZ12EZH2 | |
| SCHEMBL2883035 | 0.80 | LNPEP (0.49) | GRM5EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30676170 | 0.79 | GRM5 (0.61) | GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |