Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.58 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.58 |
| ▸ | CLK2 | P49760 | 3/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.58 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.58 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.58 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.58 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.58 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320090 | 0.92 | AXL (0.62) | AXLCAMKK2DYRK1APRKD3MAP4K4 | |
| SCHEMBL8313904 | 0.84 | DYRK1A (0.56) | AXLCAMKK2DYRK1APRKD3MAP4K4 | |
| SCHEMBL13746382 | 0.83 | CAMKK2 (0.80) | AXLCAMKK2DYRK1APRKD3MAP4K4 | |
| SCHEMBL8322030 | 0.81 | DYRK1A (0.58) | AXLCAMKK2DYRK1AMAPK9SGK1 | |
| SCHEMBL8323639 | 0.81 | PABPC1 (0.52) | AXLCAMKK2DYRK1APRKD3MAP4K4 | |
| SCHEMBL8320085 | 0.81 | AXL (0.76) | AXLCAMKK2DYRK1AMAPK9SGK1 | |
| SCHEMBL8321878 | 0.80 | ROCK1 (0.58) | DYRK1AMAPK9ROCK1KDRCLK1 | |
| SCHEMBL12829935 | 0.80 | MAPK8 (0.50) | AXLCAMKK2DYRK1AMAPK9ROCK2 | |
| SCHEMBL13746370 | 0.80 | KIT (0.52) | AXLCAMKK2DYRK1AMAPK9ROCK2 | |
| SCHEMBL8320015 | 0.80 | MAPK8 (0.65) | AXLCAMKK2DYRK1AMAPK9SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | AXL 3999/4885CAMKK2 94/4885DYRK1A 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.