Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313720 | 0.83 | NPC1 (0.52) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL9200588 | 0.83 | NPC1 (0.52) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL8314714 | 0.83 | CYP1A2 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL8312276 | 0.81 | RAB9A (0.62) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL14856022 | 0.81 | RAB9A (0.62) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL8313089 | 0.79 | NPC1 (0.46) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL8311826 | 0.76 | NPC1 (0.68) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL8313770 | 0.75 | RAB9A (0.38) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL8315644 | 0.75 | HDAC4 (0.47) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL14856486 | 0.74 | POLB (0.50) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |